Dual Transport Properties of Anion Exchanger 1

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Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis.

Anion exchanger 1 (AE1) is encoded by SLC4A1 and mediates electroneutral anion exchange across cell membranes. It is the most abundant protein in the red cell membrane, but it is also found in the basolateral membrane of renal alpha-intercalated cells, where it is required for normal urinary acidification. Recently, four point mutations in red cell AE1 have been described that convert the anion...

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TRANSLATIONAL PHYSIOLOGY Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis

Walsh SB, Borgese F, Gabillat N, Unwin RJ, Guizouarn H. Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis. Am J Physiol Renal Physiol 295: F343–F350, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00587.2007.—Anion exchanger 1 (AE1) is encoded by SLC4A1 and mediates electroneutral anion exchange across cell membranes. It is the m...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2011

ISSN: 0021-9258

DOI: 10.1074/jbc.m110.166819